Jonathan M Brotchie Selected Research

Dyskinesias (Dyskinesia)

1/2021	A novel dopamine D3R agonist SK609 with norepinephrine transporter inhibition promotes improvement in cognitive task performance in rodent and non-human primate models of Parkinson's disease.
1/2020	The Promise and Challenges of Developing miRNA-Based Therapeutics for Parkinson's Disease.
1/2019	Pridopidine, a clinic-ready compound, reduces 3,4-dihydroxyphenylalanine-induced dyskinesia in Parkinsonian macaques.
1/2019	Viewpoint: Developing drugs for levodopa-induced dyskinesia in PD: Lessons learnt, what does the future hold?
1/2019	Repurposing drugs to treat l-DOPA-induced dyskinesia in Parkinson's disease.
11/2018	Pharmacokinetic/Pharmacodynamic Correlation Analysis of Amantadine for Levodopa-Induced Dyskinesia.
1/2018	DPI-289, a novel mixed delta opioid agonist / mu opioid antagonist (DAMA), has L-DOPA-sparing potential in Parkinson's disease.
10/2016	Tor1a+/- mice develop dystonia-like movements via a striatal dopaminergic dysregulation triggered by peripheral nerve injury.
1/2016	Dopamine Reuptake Inhibitors in Parkinson's Disease: A Review of Nonhuman Primate Studies and Clinical Trials.
10/2015	The highly-selective 5-HT(1A) agonist F15599 reduces L-DOPA-induced dyskinesia without compromising anti-parkinsonian benefits in the MPTP-lesioned macaque.

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Jonathan M Brotchie Research Topics

Disease

92	Parkinson Disease (Parkinson's Disease) 01/2022 - 05/2002
68	Dyskinesias (Dyskinesia) 01/2021 - 02/2003
18	Parkinsonian Disorders (Parkinsonism) 01/2019 - 05/2002
6	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2021 - 07/2008
6	Dystonia (Limb Dystonia) 10/2016 - 01/2002
6	Psychotic Disorders (Schizoaffective Disorder) 07/2014 - 09/2006
4	Disease Progression 01/2020 - 07/2004
4	Chorea (Rheumatic Chorea) 06/2011 - 02/2004
3	Synucleinopathies 01/2019 - 01/2016
2	Dystonic Disorders (Writer's Cramp) 10/2016 - 01/2002
2	Disruptive, Impulse Control, and Conduct Disorders (Kleptomania) 02/2015 - 02/2011
2	Hyperkinesis 11/2006 - 02/2003
1	Inflammation (Inflammations) 01/2022
1	Neuroinflammatory Diseases 01/2022
1	Prodromal Symptoms 01/2021
1	Cognitive Dysfunction 01/2021
1	Channelopathies 01/2021
1	Hypokinesia (Bradykinesia) 01/2020
1	Mood Disorders (Mood Disorder) 01/2020
1	Tremor (Tremors) 01/2020
1	Huntington Disease (Huntington's Disease) 01/2019
1	Dystonia musculorum deformans type 1 10/2016
1	Neuroblastoma 10/2015
1	Mental Disorders (Mental Disorder) 10/2015
1	Bipolar Disorder (Manic Depressive Psychosis) 10/2015
1	Diabetes Mellitus 03/2015
1	Secondary Parkinson Disease (Secondary Parkinsonism) 11/2014

Drug/Important Bio-Agent (IBA)

67	Levodopa (L Dopa)FDA LinkGeneric 01/2021 - 02/2003
32	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 01/2019 - 08/2003
25	Dopamine (Intropin)FDA LinkGeneric 01/2021 - 05/2002
12	SynucleinsIBA 01/2022 - 05/2016
6	Pharmaceutical PreparationsIBA 09/2017 - 11/2005
5	Amantadine (Aman)FDA LinkGeneric 11/2018 - 07/2004
4	Proteins (Proteins, Gene)FDA Link 02/2017 - 10/2010
4	Serotonin (5 Hydroxytryptamine)IBA 01/2016 - 07/2009
4	5-HT1A Serotonin ReceptorIBA 10/2015 - 10/2011
4	Dopamine Agonists (Dopamine Agonist)IBA 02/2015 - 01/2004
4	Dihydroxyphenylalanine (Dopa)IBA 06/2013 - 02/2004
4	Levetiracetam (Keppra)FDA LinkGeneric 07/2004 - 11/2003
3	Neuroprotective AgentsIBA 01/2020 - 07/2004
3	Opioid Analgesics (Opioids)IBA 01/2018 - 01/2004
3	alpha-SynucleinIBA 01/2016 - 10/2010
3	Dopamine Agents (Dopaminergic Agents)IBA 10/2013 - 09/2008
3	Messenger RNA (mRNA)IBA 01/2012 - 10/2003
3	Reserpine (Serpasil)FDA Link 09/2010 - 02/2003
2	Norepinephrine Plasma Membrane Transport Proteins (Norepinephrine Transporter)IBA 01/2021 - 01/2015
2	TrehaloseIBA 01/2019 - 05/2016
2	Sirtuin 3IBA 08/2018 - 10/2017
2	Narcotic Antagonists (Opioid Antagonists)IBA 01/2018 - 01/2004
2	oxidized low density lipoproteinIBA 01/2018 - 03/2013
2	Catechol O-Methyltransferase (Methyltransferase, Catechol)IBA 01/2016 - 03/2013
2	Dopamine Plasma Membrane Transport Proteins (Dopamine Transporter)IBA 01/2016 - 01/2015
2	3- ((4- (4- chlorophenyl)piperazin- 1- yl)methyl)- 1H- pyrrolo(2,3- b)pyridineIBA 02/2015 - 08/2012
2	N- methyl- 1- cyclopropyl- 1- piperonylmethylamineIBA 07/2014 - 01/2012
2	Neurotransmitter Agents (Neurotransmitter)IBA 02/2013 - 01/2013
2	N-Methyl-3,4-methylenedioxyamphetamine (MDMA)IBA 05/2012 - 05/2011
2	N- (2- (4- (2- methoxyphenyl)- 1- piperazinyl)ethyl)- N- (2- pyridinyl)cyclohexanecarboxamideIBA 05/2012 - 01/2012
2	Quetiapine Fumarate (Seroquel)FDA Link 05/2012 - 11/2006
2	Clozapine (Clozaril)FDA LinkGeneric 05/2012 - 11/2006
2	Antipsychotic Agents (Antipsychotics)IBA 05/2012 - 11/2006
2	Adrenergic Receptors (Adrenergic Receptor)IBA 01/2012 - 08/2003
2	5-HT2A Serotonin Receptor (5 HT2A Receptor)IBA 01/2012 - 10/2011
2	Histamine (Histamine Dihydrochloride)FDA Link 07/2010 - 07/2007
2	Haloperidol (Haldol)FDA LinkGeneric 09/2008 - 11/2006
2	EndocannabinoidsIBA 07/2005 - 07/2005
2	preproenkephalinIBA 01/2004 - 10/2003
2	Opioid Peptides (Opioid Peptide)IBA 01/2004 - 10/2003
2	ropinirole (Requip)FDA LinkGeneric 01/2004 - 11/2003
2	CB1 Cannabinoid Receptor (CB1 Receptor)IBA 02/2003 - 02/2003
1	CytokinesIBA 01/2022
1	RNA (Ribonucleic Acid)IBA 01/2022
1	AntigensIBA 01/2022
1	MicroRNAs (MicroRNA)IBA 01/2020
1	G(M1) GangliosideIBA 10/2019
1	pridopidineIBA 01/2019
1	DisaccharidesIBA 01/2019
1	Capsules (Microcapsules)IBA 11/2018
1	N-Methylaspartate (NMDA)IBA 11/2018
1	Protein Isoforms (Isoforms)IBA 06/2018
1	DPI-289IBA 01/2018
1	Monoamine Oxidase Inhibitors (Monoamine Oxidase Inhibitor)IBA 01/2016
1	Dopamine Uptake Inhibitors (Dopamine Reuptake Inhibitors)IBA 01/2016
1	Norepinephrine (Noradrenaline)FDA LinkGeneric 01/2016
1	JNX1001IBA 10/2015
1	Brain-Derived Neurotrophic Factor (BDNF)IBA 10/2015
1	RotenoneIBA 10/2015
1	3- chloro- 4- fluorophenyl- (4- fluoro- 4- (((5- methylpyrimidin- 2- ylmethyl)amino)methyl)piperidin- 1- yl)methanoneIBA 10/2015
1	Biomarkers (Surrogate Marker)IBA 08/2015
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 03/2015
1	PPAR gammaIBA 03/2015
1	Pioglitazone (Actos)FDA Link 03/2015
1	Dopamine D4 Receptors (Dopamine D4 Receptor)IBA 02/2015
1	Serotonin Plasma Membrane Transport Proteins (Serotonin Transporter)IBA 01/2015
1	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 10/2013
1	TC-8831IBA 10/2013
1	CLR151IBA 06/2013
1	Dopamine AntagonistsIBA 06/2013

Therapy/Procedure

25	Therapeutics 01/2021 - 02/2003
3	Deep Brain Stimulation 06/2017 - 01/2013
1	Nerve Crush 10/2016